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5 Days of Stem Cells
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Nick Radio

Thermo Fisher Scientific

New enabling technologies for 3D quantitative cellular biology using High-Content Screening

Abstract:

High-Content Screening is an image cytometry-based methodology used to measure cellular and small organism biologies amendable to screening in the drug discovery space.  Using both transmitted and fluorescent light techniques, the automated nature of both the imaging and quantitative analysis enables the throughput ability to measure numerous time points and pharmacological concentrations that are both time and resource-prohibitive to accomplish using conventional, manual methods.  This technical seminar will provide an overview of pharmacological applications where the technology is applied, including receptor activation, intracellular signaling, and concomitant phenotypic screening.  The seminar will also review advances in 3-dimensional High Content Screening techniques as it applies to spheroid, whole animal and thick tissue specimens. Finally, we will provide a preview of our new HCS Studio 4.0 software including EurekaScan Finder to accelerate screening of spheroids, tissue and rare events.